Plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine. Evidence for extensive phospholipase A1 hydrolysis and hepatic metabolism of the products.
نویسندگان
چکیده
منابع مشابه
Evidence for receptor and G-protein regulation of a phosphatidylethanolamine-hydrolysing phospholipase A1 in guinea-pig heart microsomes: stimulation of phospholipase A1 activity by DL-isoprenaline and guanine nucleotides.
While evidence has been presented for the receptor-mediated activation of phospholipases A2, C and D, the activation of phospholipase A1 subsequent to receptor activation has not been established. Phospholipase A1-catalysed hydrolysis of 1-palmitoyl-2-linoleoyl-glycerophosphoethanolamine (GPE) by guinea-pig heart microsomes was stimulated 40-60% by isoprenaline. This isoprenaline-mediated incre...
متن کاملPhospholipase C - mediated Hydrolysis of Phosphatidylcholine
We have investigated the effect of cis-diamminedichloroplatinum(II) (CDDP) on signal transduction pathways. CDDP treatment did not cause any change in the binding of 1H1phorbol dibutyrate to PC-9 (human lung adenocarcinoma cell line) cells, a measure of protein kinase C activation. However, 2-h CDDP treatment (20 gg/ml) caused 200% increase in 1,2-sn-diacylglycerol (DAG) production and 50% decr...
متن کاملEnzymatic measurement of ether phospholipids in human plasma after hydrolysis of plasma with phospholipase A1
Objectives Ethanolamine ether phospholipids (ePE) and choline ether phospholipid (ePC) are present in human serum or plasma. Decreases in ether phospholipids (plasmalogens) in serum (plasma) have been reported in several diseases such as Alzheimer's disease, Parkinson's disease, metabolic syndrome, schizophrenia. Therefore, need for assay of ether phospholipids in plasma may increase in the fut...
متن کاملSignal-dependent activation of phosphatidylcholine hydrolysis: role of phospholipase D.
29. Brooks, G., Evans, A. T., Aitken, A. & Evans, F. J. (1987) Cancer Lett. 38,165-170 Evans, A. T., Brooks, G. & Evans, F. J. (1990) Cancer Lett. 49,2529 Evans, F. J., Kinghorn, A. D. & Schmidt, R. J. (1975) Acta Pharmacol. Toxicol. 37,250-256 Tapley, P. M. & Murray, A. W. (1985) Eur. J. Biochem. 151,419-423 Edwards, M. C., Williamson, E. M., Formakong, E., Brooks, G. & Evans, F. J. (1987) Bio...
متن کاملThe interaction of alpha-tocopherol with bilayers of 1-palmitoyl-2-oleoyl-phosphatidylcholine.
The effect of alpha-tocopherol on the structure and phase behaviour of 1-palmitoyl-2-oleoyl-phosphatidylcholine was examined by real-time synchrotron X-ray diffraction and freeze-fracture electron microscopic methods. X-ray scattering intensity was recorded from mixed aqueous dispersions of phospholipid with 2.5, 5, 10 and 20 mol% alpha-tocopherol during temperature scans at 3 degrees /min betw...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55229-7